known that full length BMP-2 protein induces osteogenic differentiation and
endochondral ossification in mesenchymal stem cells as it is a vital
morphogenetic agent that organizes the architecture of tissue throughout the
body(Assoian et al., 1983).
In the framework of the “minimization”
of the molecular length of full length proteins we studied the carboxyl protein
domain of BMP-2 (283-Val.. Arg-396) regarding osteogenesis. We conducted the
same studies in order to identify short protein domains of full length TGF-b1
growth factor towards chondrogenesis.