Opioids are medications used to treat moderate to severe pain after an injury, surgery or during some chronic disease process when all the other painkillers have failed to alleviate the pain. They sometimes are also used for the suppression of a cough and diarrhea. They include Codeine, Fentanyl, Hydrocodone, Morphine, Oxycodone, Tramadol etc. Substance abuse disorders including opioids during pregnancy is a grave issue that needs to be carefully focused and dealt. It prevails in all ethnic, racial, and socioeconomic groups and affects womenbelonging to urban, suburban and rural areas. The use of opioids has burgeoned theatrically in the past few years. According to a study, 22.8% of women that were registered in Medicaid programs in 46 states of the United States, filled an opioid prescription during their pregnancy in 2007. According to another study, which observed hospital discharge cards, demonstrated an increment in maternal opioid use nearly fivefold in only 9 years from 2000 to 2009, during their antepartum period. Consequences of Opioids Usage in Pregnancy:Opioids are considered as dangerous drugs because of their intense addictive potential. Once addicted, a person loses his self-control and ability to quit taking the drugs. During pregnancy, chronic opioid addiction is associated with poor prenatal care, involvement in high-risk activities such as criminal acts and trading sex for drugs which expose the women to violence and legal proceedings and also increase the risk of getting Sexually Transmitted Infections including HIV, Hepatitis, Syphilis etc. These women have also reported having certain psychological conditions, particularly anxiety, depression, mood swings, post-traumatic stress disorder etc. A research showed that greater than 30% of pregnant women screened positive for moderate to severe depression, who participated in a substance use treatment program, and greater than 40% developed symptoms of postpartum depression as well. Most of the pregnant women are aware of the consequences of smoking, alcohol consumption, and drug abuse on their babies and on themselves but because of the addiction and dependence, they are unable to stop using them. This can bring some drastic effects to the mothers and the babies as well. Following is a list and brief description of some of the detrimental effects that can occur to the babies:• Miscarriage: Which is the end of pregnancy within the first 20 weeks of gestation.• Preterm Birth: Which is when a mother delivers a baby before reaching the full-term gestational period i.e. 37 weeks. Babies born early are prone to have health-related problems more than the full-term babies later in life. • Fetal Growth Retardation: It refers to a condition in which the fetus has a poor growth during the gestational period. • Birth Defects: Babies born to the mothers who are substance abusers are more likely to have birth defects. These are a group of conditions in which a body part is missing or not formed properly. Heart defects, cleft lip and/or palate, neural tube defects, clubfoot etc. are some of the common examples. A baby can have one or more of these defects at the time of birth. They can create problems in health overall. • Seizures: Seizures can present as one of the most dramatic drug-related abnormality in the Central Nervous System of newborns which can even lead to the death of a baby. • Sudden Infant Death Syndrome (SIDS): Also called cot death or crib death, is an unexplained demise of an otherwise healthy-looking baby of less than 1 year of age, usually during sleep. Opioids use by their mothers during gestation is one of the leading risk factors of it. • Neonatal Abstinence Syndrome (NAS): A group of problems that happen to a baby who is exposed to licit or illicit drugs in the uterus of his mother. NAS is most commonly a result of opioid usage during pregnancy. A recent study conducted by National Institute of Drug Abuse (NIDA) concluded that a baby suffering from Opioid Withdrawal is born every 25 minutes. Regions that have the highest rates of opioid prescription also have the highest rates of this problem. The Centers for Disease Control and Prevention (CDC) found that the incidence of neonatal abstinence syndrome has jumped up from 1.5 per 1000 births in 1999 to 6 per 1000 births in 2013 in the U.S. Babies born with NAS are more prone to have the following signs and symptoms:o Tremors, tight muscles and overactive reflexeso Low Birth Weight o Excessive or high-pitched cryo Breathing difficultieso Feeding difficultieso Vomiting or diarrheao Temperature instability o Sweating or blotchy- skin Opioid use disorder is a chronic yet treatable issue that can be managed efficiently by combining medications, behavioral therapy, detox programs, rehabilitation and support during the recovery. This allows those with opioid use disorder to regain their health and live a delightful life ahead. Timely screening, appropriate interventions, and referral for rehabilitation of pregnant women with opioid use and its disorder can certainly ameliorate the outcomes in the lives of mothers and infants and can provide them a firm chance to create a lasting difference in their lives.