We have developed several methods for the treatment of
cancer like surgery, chemotherapy, radiation therapy, hormonal therapy, etc.
But curing cancer with near-zero adverse effect is not possible with these
methods. Conventional chemotherapeutic agents had several drawbacks like low
solubility, low stability, cytotoxicity etc. With time several new approaches
have been developed for targeted drug delivery and precision medium and now we
stand with nanomedicine in our hand. DNA origami is the advanced approach under the nanotechnology discipline which provide promising diagnostic and therapeutic
strategy.

DNA origami is folding of DNA at nanoscale level to create
two and three dimensional shapes. DNA is
a biomolecule with molecular self-assembly property. As the complementary
sequences can bind to one another, individual
molecule of the right sequence will assemble by themselves into intricate shape
and structure at nanoscale. Long ssDNA
called ‘scaffold’ are folded with the help of hundreds of short ssDNA called
‘staples’ that hold the scaffold in place.

We Will Write a Custom Essay Specifically
For You For Only $13.90/page!


order now

Various shapes have been designed like DNA triangle, DNA
nanotubes, rod-like DNA nanostructures. Drugs are loaded inside them and are released only at target site. Data shows that DNA nanostructures
allow the drugs, the enzymes to be more stable, more catalytically active and
more resistant to protease digestion. DNA origami nanostructures with doxorubicine resulted in increased apoptosis of
doxorubicin-resistant breast cancer cells when injected in cancer infected
mice. Shape and structure of DNA origami nanostructures affects a lot of factors like stability, drug loading and releasing
capabilities, cellular internalization etc. Reports show that more drug could
be loaded in 3-D origami structure but released faster in 2-D origami structure.
DNA nanoribbons with high length to width ratios are preferentially
internalized by cells. DNA nanostructures are biocompatible and biodegradable,
but they can be modified with wide range
of functional entities such as aptamers, lipids, protein and inorganic
nanomaterial making DNA nanostructures an attractive platform for the
development of drug delivery system.

Cancer refers to a class of diseases, it was unlikely that
there will ever be a single cure for ‘cancer’, but DNA nanostructures pave a
way for more stable, more efficient, more specific and near-zero effect
treatment.

 

My work interest lies in finding new shapes and structures
that can improve the uptake, release and specificity of the drug, also I would
like to work on finding better methods to make these structures more stable and
efficient.